解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Congenital adrenal hyperplasia is a group of common inherited disorders leading to glucocorticoid deficiency. Most cases are caused by 21-hydroxylase deficiency (21OHD). The systemic consequences of imbalanced steroid hormone biosynthesis due to severe 21OHD remains poorly understood. Therefore, we developed a zebrafi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00549
更新日期:2017-12-01 00:00:00
abstract::The endocrine-disrupting chemical bisphenol A (BPA) increases adipose tissue mass in vivo and promotes adipogenesis in vitro; however, mechanisms explaining BPA's obesogenic effect remain unknown. We investigated the effects of gestational BPA and its analog, bisphenol S (BPS), exposure on the adipogenic differentiati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00615
更新日期:2017-11-01 00:00:00
abstract::Spermatogenesis is sustained by a heterogeneous population of spermatogonia that includes the spermatogonial stem cells. However, the mechanisms underlying their establishment from gonocyte embryonic precursors and their maintenance thereafter remain largely unknown. In this study, we report that inactivation of the u...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00396
更新日期:2017-11-01 00:00:00
abstract::Although kisspeptin is the primary stimulator of gonadotropin-releasing hormone secretion and therefore the hypothalamic-pituitary-gonadal axis, recent findings suggest kisspeptin can also regulate additional neuroendocrine processes including release of growth hormone (GH). Here we show that central delivery of kissp...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00303
更新日期:2017-10-01 00:00:00
abstract::Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β superfamily and plays a critical role in regulating ovarian follicle function. Currently, the role of BMP2 during cumulus expansion remains to be determined. The aim of this study was to investigate the effect of BMP2 on the regulation of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00436
更新日期:2017-10-01 00:00:00
abstract::The thyroid hormone (TH) analog eprotirome (KB2115) was developed to lower cholesterol through selective activation of the TH receptor (TR) β1 in the liver. Interestingly, eprotirome shows low uptake in nonhepatic tissues, explaining its lipid-lowering action without adverse extrahepatic thyromimetic effects. Clinical...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00433
更新日期:2017-10-01 00:00:00
abstract::Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein "dilution" has been explained by resource-mediated trade-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00331
更新日期:2017-10-01 00:00:00
abstract::Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00196
更新日期:2017-09-01 00:00:00
abstract::Trans-10, cis-12 conjugated linoleic acid (10,12 CLA) is a dietary fatty acid that promotes weight loss and disproportionate fat loss. Obese mice fed a high-fat, high-sucrose (HFHS) diet containing 10,12 CLA are resistant to weight gain and contain markedly reduced subcutaneous fat and adiponectin, with a concurrent l...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00213
更新日期:2017-09-01 00:00:00
abstract::Exposure to estrogen during the developmental period causes reproductive dysfunction in mammals, because the developing brain is highly sensitive to estrogens. In the present study, we report that long-term exposure to supraphysiological doses of estrogen during the neonatal critical period causes irreversible suppres...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1144
更新日期:2017-09-01 00:00:00
abstract::The mineralocorticoid receptor (MR) is a member of the steroid-thyroid hormone receptor superfamily of ligand-dependent transcription factors with diverse functions including the biological actions of aldosterone. Identification of the various transcriptional coregulators of MR is essential for understanding the compl...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00095
更新日期:2017-07-01 00:00:00
abstract::Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1916
更新日期:2017-07-01 00:00:00
abstract::Age-related bone loss is an important risk factor for fractures in the elderly; it results from an imbalance in bone remodeling mainly due to decreased bone formation. We have previously demonstrated that endogenous G protein-coupled receptor (GPCR)-driven Gi signaling in osteoblasts (Obs) restrains bone formation in ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1365
更新日期:2017-06-01 00:00:00
abstract::Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which can amplify...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1722
更新日期:2017-06-01 00:00:00
abstract::3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone (TH)-derived metabolite that induces severe hypothermia in mice after systemic administration; however, the underlying mechanisms have remained enigmatic. We show here that the rapid 3-T1AM-induced loss in body temperature is a consequence of peripheral vasod...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1951
更新日期:2017-06-01 00:00:00
abstract::Obesity is associated with chronic inflammation and liver steatoses. Numerous proinflammatory cytokines have been reported to regulate liver glucose and lipid metabolism, thus contributing to the pathogenesis of liver steatosis and/or metabolic dysfunction. Nuclear factor-κB-inducing kinase (NIK) is stimulated by many...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1582
更新日期:2017-05-01 00:00:00
abstract::Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites are dependent on the activity o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1929
更新日期:2017-05-01 00:00:00
abstract::The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2016-1944
更新日期:2017-05-01 00:00:00
abstract::Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, the protein hypoxia-inducible lipid droplet-associated (HILPDA) was localized to lipid droplets and was suggested to inhibit...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1809
更新日期:2017-05-01 00:00:00
abstract::Bisphenol-A (BPA) is a component of polycarbonate and other plastics to which humans are regularly exposed at low levels. BPA is characterized as an endocrine disruptor because of observations of its estrogenic activity in various experimental models. We have previously shown evidence of disrupted hypothalamic feeding...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1718
更新日期:2017-04-01 00:00:00
abstract::Loss-of-function mutations in the X-linked immunoglobulin superfamily, member 1 (IGSF1) gene cause central hypothyroidism. IGSF1 is a transmembrane glycoprotein of unknown function expressed in thyrotropin (TSH)-producing thyrotrope cells of the anterior pituitary gland. The protein is cotranslationally cleaved, with ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1788
更新日期:2017-04-01 00:00:00
abstract::Synthetic glucocorticoids (GCs), including dexamethasone (DEX), are powerful anti-inflammatory drugs. Long-term use of GCs, however, can result in metabolic side effects such as hyperglycemia, hepatosteatosis, and insulin resistance. The GC receptor (GR) and liver X receptors (LXRα and LXRβ) regulate overlapping genes...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00094
更新日期:2017-04-01 00:00:00
abstract::Hyperandrogenism, disturbance of the hypothalamus-pituitary-ovary axis followed by elevated serum luteinizing hormone (LH) levels, and insulin resistance are involved in the complicated pathophysiology of polycystic ovary syndrome (PCOS). Kisspeptin is coexpressed with neurokinin B (NKB) in the arcuate nucleus (ARC), ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1333
更新日期:2017-02-01 00:00:00
abstract::Excessive accumulation of body fat triggers insulin resistance and features of the metabolic syndrome. Recently, evidence has accumulated that obesity, type 2 diabetes, and metabolic syndrome are associated with reduced levels of serum prolactin (PRL) in humans and rodents, raising the question of whether low PRL leve...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1444
更新日期:2017-01-01 00:00:00
abstract::Bisphenol A (BPA) is an endocrine-disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts, and many other everyday items and is detectable in human urine and blood. Exposure to BPA during development can disrupt sexual differentiation of some brain regions. Mo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1188
更新日期:2017-01-01 00:00:00
abstract::Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase 2-inhibitor beloranib (ZGN-440) in 2 male rat models of obesity, one modeling hypothalamic obesity with a combined me...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1665
更新日期:2017-01-01 00:00:00
abstract::Adult Leydig cells are derived from proliferating stem/progenitor Leydig cells in the infant testis and subsequent differentiation to steroidogenic cells in adult mice. Leydig cell proliferation in the infant testis occurs primarily in response to increased levels of LH that induce Leydig cell expression of neuregulin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1478
更新日期:2016-12-01 00:00:00
abstract::There is now general agreement that neurokinin B (NKB) acts via neurokinin-3-receptor (NK3R) to stimulate secretion of GnRH and LH in several species, including rats, mice, sheep, and humans. However, the roles of two other tachykinins, substance P (SP) and neurokinin A, which act primarily via NK1R and NK2R, respecti...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1565
更新日期:2016-12-01 00:00:00
abstract::Specialized metabolic sensors in the hypothalamus regulate blood glucose levels by influencing hepatic glucose output and hypoglycemic counterregulatory responses. Hypothalamic reactive oxygen species (ROS) may act as a metabolic signal-mediating responses to changes in glucose, other substrates and hormones. The role...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-2054
更新日期:2016-12-01 00:00:00
abstract::The circadian rhythm of glucocorticoids affects diverse physiological systems, including stress responses and the coordination of rhythmic functions in peripheral and central tissues. Circadian clocks are considered to be important coordinators of glucocorticoid release and loss of the core clock component Brain and m...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1330
更新日期:2016-11-01 00:00:00
abstract::Peroxisome proliferator activated receptor (PPARγ) is a nuclear receptor transcription factor that regulates adipogenesis and energy homeostasis. Recent studies suggest PPARγ may mediate some of its metabolic effects through actions in the brain. We used a Cre-recombinase-dependent (using NestinCre) conditionally acti...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1524
更新日期:2016-11-01 00:00:00
abstract::Glucocorticoid (Gc) excess, from endogenous overproduction in disorders of the hypothalamic-pituitary-adrenal axis or exogenous medical therapy, is recognized to cause adverse metabolic side effects. The Gc receptor (GR) is widely expressed throughout the body, including brain regions such as the hypothalamus. However...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1571
更新日期:2016-11-01 00:00:00
abstract::Endocrine-disrupting chemicals (EDCs) that interfere with the steroid axis can affect amelogenesis, leading to enamel hypomineralization similar to that of molar incisor hypomineralization, a recently described enamel disease. We investigated the sex steroid receptors that may mediate the effects of EDCs during rat am...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1342
更新日期:2016-11-01 00:00:00
abstract::Progesterone released by cumulus cells surrounding the egg induces a Ca2+ influx into human sperm cells via the cationic channel of sperm (CatSper) Ca2+ channel and controls multiple Ca2+-dependent responses essential for fertilization. We hypothesized that chemical UV filters may mimic the physiological action of pro...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1473
更新日期:2016-11-01 00:00:00
abstract::Increased expression of bone morphogenetic proteins (BMPs) in several tissues is associated with inflammation and type 2 diabetes mellitus. BMP2 and BMP4 mRNA expression is increased in pancreatic islets from db/db mice and β-cell proliferation and function are inhibited by BMP4. The effect of BMPs on α-cells is curre...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1163
更新日期:2016-10-01 00:00:00
abstract::Glucose homeostasis depends on the coordinated secretion of glucagon, insulin, and Glucagon-like peptide (GLP)-1 by pancreas and intestine. Obesity, which is associated with an increased risk of developing insulin resistance and type 2 diabetes, affects the function of these organs. Here, we investigate the functional...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1433
更新日期:2016-10-01 00:00:00
abstract::Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor (PGR), PGR membrane component 1, in regulating female fertility. To achieve this goal, the Pgrmc1 gene was floxed by insertion of loxP sites on each side of exon 2...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1081
更新日期:2016-09-01 00:00:00
abstract::The suprachiasmatic nucleus (SCN) and arcuate nucleus (ARC) have reciprocal connections; catabolic metabolic information activates the ARC and inhibits SCN neuronal activity. Little is known about the influence of the SCN on the ARC. Here, we investigated whether the SCN modulated the sensitivity of the ARC to catabol...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1751
更新日期:2016-09-01 00:00:00
abstract::Prolactin (PRL) is a vertebrate hormone with diverse actions in osmoregulation, metabolism, reproduction, and in growth and development. Osmoregulation is fundamental to maintaining the functional structure of the macromolecules that conduct the business of life. In teleost fish, PRL plays a critical role in osmoregul...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1969
更新日期:2016-09-01 00:00:00
abstract::Neurotensin (NT) is a peptide expressed in the brain and in the gastrointestinal tract. Brain NT inhibits food intake, but the effects of peripheral NT are less investigated. In this study, peripheral NT decreased food intake in both mice and rats, which was abolished by a NT antagonist. Using c-Fos immunohistochemist...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1329
更新日期:2016-09-01 00:00:00